Subject(s)
Humans , Male , History, 20th Century , History, 21st Century , Research/history , Neurosciences/history , Faculty , Memory/physiology , PharmacologyABSTRACT
El desarrollo histórico inicial de la neurología peruana tiene como figura a Oscar Trelles quien funda las bases de su progreso. Sin embargo, aún no se ha descrito los hitos ni las personalidades notables de la neurología peruana en la segunda mitad del siglo XX en adelante. El objetivo de este trabajo fue escribir la etapa científica de la neurología en el Perú durante la segunda mitad del siglo XX, proponiendo la obra de Pedro Ortiz Cabanillas como una propuesta disruptiva e innovadora en la neurología. Durante la segunda mitad del siglo XX, se diverjo las escuelas formadoras de neurología en la Universidad Nacional Mayor de San Marcos y la Universidad Peruana Cayetano Heredia, sendas representada por Honorio Delgado y Oscar Trelles. Durante la segunda mitad del siglo XX, Pedro Ortiz da forma a la información como la materia que organiza a los sistemas vivos, en su Teoría Sociobiológica Informacional. En esta plantea que la información se a complejizado en cinco niveles organizativos de sistemas vivos. Conforme las consideraciones de desarrollo de la neurología en la segunda mitad del siglo XX en el Perú, resaltamos a Pedro Ortiz como un pionero que propone una redefinición del entendimiento de la información en los sistemas vivos.
The initial historical development of Peruvian neurology includes Oscar Trelles who is the founder of the groundwork and its progress. However, the milestones of noteworthy individuals in Peruvian neurology work, during the second half of the 20th century and beyond, have not yet been described. The objective of this work was to address the scientific stage of neurology in Peru during the second half of the 20th century, proposing the work of Pedro Ortiz Cabanillas as a disruptive and innovative proposal in neurology. During the second half of the 20th century, the neurology training schools were divided into the National University of San Marcos and the Universidad Peruana Cayetano Heredia, represented by Honorio Delgado and Oscar Trelles. During the second half of the twentieth century, Pedro Ortiz relates information as the material that organizes living systems, in his Informational Sociobiological Theory. In this work it is stated that information becomes more complex in five organizational levels of living systems. According to the development considerations of neurology in the second half of the 20th century in Peru, we highlight Pedro Ortiz as a pioneer who proposes a redefinition of the understanding of information in living systems.
Subject(s)
History, 20th Century , Sociobiology/history , Neurology/history , Peru , Neurosciences/historyABSTRACT
Luigi Luciani (1840-1919) was an illustrious Italian citizen and physiologist whose research scope covered mainly cardiovascular subjects, the nervous system, and fasting. He published in 1891 a modern landmark of the study of cerebellar physiology - "Il cervelletto: nuovistudi di normal and pathología physiology" / "The cerebellum: new studies on normal and pathological physiology." In his experiment, a dog survived after cerebellectomy, reporting a triad of symptoms (asthenia, atonia, and astasia). In this way, the eminent neurophysiologist improved the operative technique and sterile processes to redirect the issue of cerebellar symptoms. Luciani died at age 78, a hundred years ago, and left mainly the understanding of the role of the cerebellum in regulating postural tone and muscle strength, which represented a step forward in understanding cerebellar motor physiology. In recent decades, cognitive / aï¬ective function has been added to the cerebellar motor, and there has also been a better understanding of cerebellar circuits.
Luigi Luciani (1840-1919) foi um ilustre cidadão e fisiologista italiano, cujo escopo de pesquisa abrangia principalmente assuntos cardiovasculares, sistema nervoso e jejum. Ele publicou em 1891 um marco moderno do estudo da fisiologia do cerebelo - "Il cervelletto: nuovistudi di fisiologia normale and patologica" / "O cerebelo: novos estudos sobre fisiologia normal e patológica". Em seu experimento, um cão sobreviveu após a cerebelectomia, com o relatório de uma tríade de sintomas (astenia, atonia e astasia). Dessa maneira, o eminente neurofisiologista aprimorou a técnica operatória e os processos estéreis para redirecionar a questão dos sintomas cerebelares. Luciani morreu aos 78 anos, cem anos atrás, e deixou principalmente a compreensão do papel do cerebelo na regulação do tônus postural e da força muscular, o que representou um passo adiante na compreensão da fisiologia motora cerebelar. Nas últimas décadas, a função cognitivo / afetiva foi adicionada à motora cerebelar e, também, houve uma melhor compreensão dos circuitos do cerebelo.
Subject(s)
Humans , History, 19th Century , History, 20th Century , Neurosciences/history , Cerebellum/physiology , Neurophysiology/history , Cerebellum/injuries , ItalyABSTRACT
Nacido en Petilla de Aragón, España, Santiago Ramón y Cajal posiblemente sea, por el volumen significativo y trascendencia de su obra, el más relevante neurocientífico de la historia. En conmemoración a la celebración en 2016 de la tercera jornada científica de la cátedra Santiago Ramón y Cajal, es objetivo de este trabajo rendir tributo al histólogo, patólogo, y neurocientífico. Se recogen de manera historiográfica momentos trascendentales de la vida y obra del sabio español, relacionados con su intensa labor investigativa, que lo llevaron al planteamiento de la teoría neuronal, la obtención del premio Nobel, la trascendencia de sus descubrimientos, así como los principales momentos de su estancia en Cuba (AU).
Born in Petilla de Aragón, Spain, Santiago Ramón y Cajal is probably, the most relevant neuroscientist of the history, due to the significant volume and transcendence of his work. Commemorating the celebration of the third scientific event of the Cathedra Santiago Ramón y Cajal in 2016, the aim of this work is rendering homage to the outstanding histologist, pathologist and neuroscientist. In a historiographical way, some significant moments of the Spanish scholar's life and work are mentioned here, related to its intense research work that lead him to postulate the neuronal theory and obtaining the Nobel prize; the transcendence of his discoveries and the main moments of his staying in Cuba are also brought about (AU).
Subject(s)
Humans , Male , History, 19th Century , History, 20th Century , Physicians , Mental Recall , Neurosciences/history , Neuroanatomy , Nobel Prize , Schools, Medical , Spain/ethnology , Biographies as Topic , Cuba/ethnology , Scientific Domains , Academies and Institutes/history , Health Facilities/history , History of Medicine , Medical Staff/history , Nervous System/anatomy & histologyABSTRACT
Abstract Since the 1990s, several disciplines have emerged at the interface between neuroscience and the social and human sciences. For the most part, they aim at capturing the commonalities that underlay the heterogeneity of human behaviors and experiences. Neuroanthropology and cultural neuroscience, or the “neurodisciplines of culture,” appear different, since their goal is to understand specificity rather than commonality and to address how cultural differences are inscribed in the brain. After offering an overview of these disciplines, and of their relation to endeavors such as cultural psychology and social neuroscience, this article discusses some of the most representative studies in the area in order to explore in which ways they are relevant for an understanding of culture.
Resumo Desde a década de 1990, várias disciplinas surgiram na interface entre neurociência e as ciências sociais e humanas. A maior parte delas procura capturar as semelhanças subjacentes à heterogeneidade de comportamentos e experiências humanas. Neuroantropologia e neurociência cultural, ou as “neurodisciplinas da cultura”, parecem à primeira vista diferentes, uma vez que seus objetivos são compreender as especificidades em vez das semelhanças e abordar como as diferenças culturais são inscritas no cérebro. Depois de oferecer uma visão geral dessas disciplinas e de sua relação com áreas como a psicologia cultural e a neurociência social, este artigo discute alguns dos estudos mais representativos na área, a fim de explorar de que forma são relevantes para a compreensão da cultura.
Subject(s)
Humans , History, 20th Century , History, 21st Century , Anthropology, Cultural , Culture , Neurosciences , Anthropology, Cultural/history , Neurosciences/historyABSTRACT
ABSTRACT The year 2016 marks the centenary of the birth of Francis Crick (1916–2004), who made outstanding contributions to genetics and neuroscience. In 1953, in a collaborative study, Francis Crick and James Watson discovered the DNA double helix, and in 1962 they and Maurice Wilkins were awarded the Noble Prize in Physiology or Medicine. Crick subsequently became very interested in neuroscience, particularly consciousness and its relationship to the claustrum, a small gray matter structure between the insula and putamen.
RESUMO O ano de 2016 é o centenário de nascimento de Francis Crick (1916–2004), físico, biólogo e neurocientista, cujas contribuições para a genética e a neurociência foram magníficas. Crick, em um estudo colaborativo com Watson, descobriu a estrutura molecular do DNA (dupla hélice) em 1953, e em 1962 ambos receberam o prêmio Nobel de Fisiologia ou Medicina, junto com Wilkins. Após Crick tornou-se muito interessado na área de neurociência, particularmente no estudo da consciência, e a sua relação com o claustrum, uma pequena estrutura de substância cinzenta localizada entre a ínsula e o putame.
Subject(s)
History, 20th Century , History, 21st Century , Genetics/history , Neurosciences/history , Basal Ganglia/physiology , DNA , Nobel PrizeABSTRACT
Se realiza un análisis histórico sobre las ideas, creencias y conceptos que se tenían de los nervios craneales en distintas épocas desde Galeno en el siglo II, haciendo comparaciones de los distintos aportes y nombres dados a estas estructuras nerviosas. Se comprueba que con el desarrollo y avance de las distintas ideas y demostraciones experimentales, se ha llegado a una comprensión más clara y precisa de las características neuroanatómicas y funcionales de estos elementos del sistema nervioso, además del número total de nervios craneales que realmente existen, a través de los cuales se propagan los impulsos nerviosos desde y hacia el sistema nervioso central.
A historical analysis of ideas about beliefs and concepts that people had about cranial nerve at different times from Galen in the second century was realized, making comparisons between the different contributions and names given to these neural structures. We found that with the development and progression of different ideas and experimental demonstrations, a more clear and precise understanding of the neuroanatomical and functional elements of the nervous system was accomplished , in addition to the total number of cranial nerves that actually exist, which propagate nerve impulses to and from the central nervous system.
Subject(s)
Humans , History, Ancient , History, 15th Century , History, 16th Century , History, 17th Century , History, 18th Century , History, 19th Century , History, 20th Century , Cranial Nerves/anatomy & histology , Neuroanatomy/history , Neurosciences/historyABSTRACT
Vladimir Mikhailovich Bekhterev was a Russian innovative neuroscientist, extraordinary in the study, diagnosis, and research in the fields of neurology, psychology, morphology, physiology, and psychiatry. Considering the ample and multifaceted scientific feats, only some are touched in a very brief manner. However, it is necessary to highlight his contributions to neurology, with the description of structures, signs and syndromes, to physiology, including reflexology, which later underpinned behaviorism, to psychology, including objective psychology and suggestion. His accomplishments and legacy remained until the present days. Some comments about the scenery that involved his death are also presented.
Vladimir Mikhailovich Bekhterev foi um neurocientista russo inovador, extraordinário no estudo, diagnóstico, e pesquisa nas áreas da neurologia, psicologia, morfologia, fisiologia e psiquiatria. Considerando seus feitos científicos amplos e multifacetados, apenas alguns são tocados de um modo muito abreviado. Entretanto, é necessário realçar suas contribuições à neurologia, com a descrição de estruturas, sinais e síndromes, à fisiologia, compreendendo a reflexologia, que mais tarde fundamentou o behaviorismo, à psicologia, incluindo a psicologia objetiva e a sugestão. Suas realizações e legado se mantiveram até a presente data. Alguns comentários sobre o cenário que envolveu sua morte também são apresentados.
Subject(s)
History, 19th Century , History, 20th Century , Neurology/history , Neurosciences/history , Psychology/history , Eponyms , Poisoning/history , RussiaABSTRACT
El médico español Don Santiago Felipe Ramón y Cajal participó en el ejercicio de la medicina militar durante la Guerra de los Diez Años de Cuba, en los hospitales de "Vista Hermosa" y "San Isidro" en Puerto Príncipe (actual provincia de Camagüey), como capitán médico de campaña. Durante su estadía, entre 1874 y 1875, enfermó de disentería y paludismo por lo que solicitó la licencia para abandonar Cuba, la cual fue otorgada el 30 de mayo de 1875, tras ser diagnosticado de caquexia palúdica grave y declarado inutilizado en campaña. Los ahorros de su desventurada estancia en Cuba fueron las bases financieras que le permitieron iniciar sus investigaciones histológicas. Se han realizado varios homenajes sobre la repercusión de la figura de Cajal en la Histología y las Neurociencias en Cuba. El objetivo del artículo es describir la estancia de Cajal en Cuba como médico militar, así como los vínculos actuales en la isla, que transitan desde su designación como Académico de Mérito de la Academia de Ciencias Médicas, Físicas y Naturales de La Habana en 1908, hasta la creación de la Cátedra Honorífica Santiago Ramón y Cajal de la Universidad de La Habana el 10 de diciembre de 2011.
Don Santiago Felipe Ramón y Cajal practiced military medicine in the Ten Year War in Cuba in "Vista Hermosa" and "San Isidro" hospitals located in Puerto Príncipe (Camagüey province today) as battlefield physician. During his stay from 1874 to 1875, he got sick from dysentery and malaria, so he asked for permission to leave Cuba and this was granted on May 30, 1875, after being diagnosed of serious malarial caquexia and declared as a soldier that could no longer be involved in the battlefield campaign. The money savings of his unfortunate stay in Cuba set the financial bases for the starting of his histological research work. There have been a number of activities to highlight the repercussion of Cajal´ s work on Histology and Neurosciences in our country. The objective of this article was to provide thorough details about the Cajal´s stay in Cuba as military physician as well as the present legacy of this personality in the island ranging from the appointment of Don Santiago as Emeritus Professor Academician of the Medical, Physical and Natural Sciences School in Havana in 1908 to the creation of the Honorary Chair "Santiago Ramón y Cajal" in Havana University on December 10th, 2011.
Subject(s)
Humans , Male , Neurosciences/history , Famous Persons , History of Medicine , Military Medicine , Nobel Prize , Spain , CubaABSTRACT
The fictional Italian author Morelli is throughout the novel “Hopscotch” (1963) Julio Cortázar's alter ego. This character proposes an unoriginal literary hypothesis in chapter 62. There is an allusion to a particular Swedish that ‘is working on a chemical theory of thought.’ The Swedish neuroscientist under analysis is Holger Hydén (1917-2000), by then professor and chairman of the Department of Histology at the University of Göteborg. Hydén, who was the first to work in neurobiological micromethods, is mentioned by Morelli due to his participation in a symposium held at the end of January 1961, in San Francisco. His pioneering work will never be completely forgotten, because Hydén's neuroscientific legacy lives and will live in Cortázar's “Hopscotch”.
.O autor italiano de ficção Morelli atua, no romance “Jogo da Amarelinha” (1963), como o
Subject(s)
History, 20th Century , Medicine in Literature , Neurosciences/history , Microdissection/historyABSTRACT
El objetivo de este trabajo es demostrar, con base en referentes de la literatura neurocientífica, que Santiago Ramón y Cajal no fue padre de la Neurociencia, pero sí uno de los pioneros de la ciencia neural. Para corroborar dicha aseveración se consultó información variada sobre Ramón y Cajal en la que se indicara que él es uno de los pioneros de la Neurociencia y se contrastó con el tiempo en que se instauró la Neurociencia como disciplina; luego se comparó dicha información con aspectos variados de otros personajes que pudieron no ser llamados fundadores de la Neurociencia. Se concluye que Santiago Felipe Ramón y Cajal no es el padre de la Neurociencia, aunque sí se resalta el que es considerado uno de los pioneros de la ciencia neural.
The present work on Santiago Ramón y Cajal aims to demonstrate on the basis of neuroscientist literature, that Santiago Ramón y Cajal was not the father or founder of Neuroscience, but is considered a neural science pioneer. In order to corroborate this statement, varied information on Ramón y Cajal was consulted within Neuroscience to determine if Ramón Y Cajal is one of the Neuroscience pioneers, and contrast that information with the beginnings of neuroscience as a discipline. Subsequently this information was compared with various aspects of other important figures who were not named Neuroscience founders. In conclusion Santiago Felipe Ramón and Cajal if not the father of Neuroscience, though it should be noted he is considered one of the pioneers of neural science.
Subject(s)
History, 19th Century , History, 20th Century , Neurosciences/history , SpainABSTRACT
Muitos dos conceitos existentes na neurociência moderna possuem suas origens nas especulações elaboradas pelos antigos filósofos e médicos gregos. Questões centrais sobre a fonte dos pensamentos humanos, o mecanismo da atividade cognitiva, e a natureza das emoções, percepção e movimento voluntário, por exemplo, foram levantadas pelos pensadores gregos. É a partir desta civilização que surgem as observações mais sistemáticas sobre a estrutura e o funcionamento do corpo, da mente e a relação entre estas duas entidades. Assim, o presente trabalho pretende observar as principais tentativas iniciais gregas em vincular estruturas do corpo (tais como o cérebro ou o coração) e atividades mentais, ao longo das diversas especulações gregas sobre a natureza, a filosofia, a psicologia e a medicina.
Many of the existing concepts in modern neuroscience have their origins in the speculations made by ancient Greek philosophers and physicians. Core questions about the source of human thought, the mechanism of cognitive activity as well as the nature of emotions, perceptions and voluntary movements, for example, were raised by Greek thinkers. It is from this civilization that arise more systematic observations on the structure and functioning of body, mind and relationship between these two entities. The present paper intends to adhere to the first Greek attempts to link structures of the body (such as the brain or the heart) and mental activities regarding various Greek speculations about the nature, philosophy, psychology and medicine.
Subject(s)
Greek World/history , Neurosciences/history , Psychophysiology/historyABSTRACT
Atualmente, o debate sobre a natureza da mente humana vem tomando novos rumos graças ao desenvolvimento de diversos estudos, no campo das neurociências, que investigam a localização das funções cerebrais. Esses trabalhos vêm contribuindo para uma melhor compreensão dos substratos neurais das funções mentais, bem como da etiologia de diversos transtornos mentais. Entretanto, o conhecimento acumulado pela neurociência não ocorreu de forma súbita. Na verdade, o estudo das relações entre o cérebro e a mente não é recente. Da pré-história aos dias atuais, surgiram vários tipos de questionamentos a respeito da possível materialidade e localização das funções mentais humana. O presente trabalho apresenta, de forma histórica, como populações pré-históricas, assim como as primeiras civilizações, localizadas no Egito, na Mesopotâmia, na Índia e na China, desenvolveram e utilizaram conceitos relacionados com a alma, a mente e o cérebro humano.
Currently, the debate about the nature of the human mind is taking new directions through the development of several studies in the field of neuroscience which investigates the location of brain functions. These studies have contributed to a better understanding of the neural substrates of mental functions and the etiology of various mental disorders. However, the knowledge developed by neuroscience did not occur abruptly. Indeed, the study of mind-brain relationship is not new. From pre-history to the present days, various different types of inquiries have been made about the possible materiality and location of human mental functions. This paper presents, in a historic manner, how prehistoric populations as well as early civilizations located in Egypt, Mesopotamia, India, and China developed and employed concepts related to the soul, the mind and the human brain.
Subject(s)
Cerebrum , Civilization/history , Mind-Body Relations, Metaphysical , Neurosciences/historyABSTRACT
O espetacular progresso das neurociências e o intenso processo de popularização, via mídia, de imagens e informações que associam a atividade cerebral a praticamente todos os aspectos da vida produzem, no imaginário social, crescente percepção do cérebro como detentor das propriedades e autor das ações que definem o que é ser alguém. Nesse contexto sociocultural, aumenta o interesse pela neuroascese, isto é, discursos e práticas a respeito de como agir sobre o cérebro para maximizar sua performance. Com o objetivo de traçar alguns elementos da história da ascese cerebral, resgatam-se momentos históricos do século XIX em que práticas neuroascéticas eram comuns. O artigo problematiza a continuidade dessas práticas na atualidade, levando em conta os diferentes contextos socioculturais e históricos nos quais se originam.
The spectacular progress of the neurosciences, as well as the intense process of popularization by the media of images and information that associate cerebral activity with practically every aspect of life, have produced a growing perception of the brain as the site and agent of all the properties and actions that define us as human beings. Today's socio-cultural context has seen increased interest in 'neuroascese', that is, discourses and practices aimed at maximizing brain performance. Tracing elements of the history of 'brain ascese' back to historical moments of the nineteenth century in which neuroascetic practices were commonplace, the article examines their continued use today, taking into account the social, cultural, and historical contexts in which they originated.
Subject(s)
History, 19th Century , History, 20th Century , Neurosciences/historyABSTRACT
The Hospício de Juquery, near the city of São Paulo (Brazil) was founded in 1896 and after few years it was decided that the institution should have the best possible facilities to study neuropathology. In 1921, a young psychiatrist, Antonio Carlos Pacheco e Silva was sent to the Hôpital de la Salpêtrière (Paris) to study neuropathology. There, Pacheco e Silva (later Prof.Pacheco e Silva) befriended Konstantin N. Tretiakoff accepted an invitation to become the first Chairman of the newly created neuropathology department of the Hospício de Juquery. During his stay in this institution, from 1922 to 1924 or early 1925, he worked very hardly and produced many publications. Here we present and comment some of the papers he published in a Journal (Memórias do Hospício de Juquery - "Memoirs de l'Hôspice de Juquery"), which had been recently created and present some information of this poorly known period of his life.
O Hospício de Juquery, perto da cidade de São Paulo (Brasil) foi fundado em 1896 e depois de poucos anos o Prof. Franco da Rocha, seu fundador, e os demais responsáveis pela instituição, com a ajuda do Governo do Estado de São Paulo, decidiram que deveriam criar as melhores instalações para o estudo da neuropatologia. Em 1921, o jovem psiquiatra Antonio Carlos Pacheco e Silva foi enviado para o Hôpital de la Salpêtrière (Paris) para estudar neuropatologia. Nessa instituição, Prof. Pacheco e Silva tornou-se amigo de um jovem neuropatologista, neurologista e psiquiatra russo Konstantin N. Tretiakoff que aceitou o desafio de chefiar o recém criado Departamento de Neuropatologia do Hospício de Juquery. Durante sua estada entre nós, de 1922 a 1924 ou início de 1925, ele trabalhou muito aplicadamente e produziu muitas publicações. Aqui nós apresentamos e comentamos alguns destes trabalhos que ele e seus associados publicaram em um novo Jornal (Memórias do Hospício de Juquery - "Memoirs de l'Hospice de Juquery") que circulou entre 1924 e 1927. Ademais, apresentamos algumas informações sobre esta parte menos conhecida de sua biografia.
Subject(s)
History, 20th Century , Hospitals, Psychiatric/history , Neurosciences/history , Brazil , RussiaSubject(s)
History, 20th Century , History, 21st Century , Psychiatry/history , Brazil , Neurosciences/historyABSTRACT
Este artigo analisa o sucesso das novas tecnologias de visualização médica, as quais têm dado relevância ao interior do corpo humano que não encontra precedentes nas nossas sociedades. Essas tecnologias extrapolam o campo estritamente biomédico e se introduzem no campo cultural e jurídico. O artigo traça uma genealogia das diferentes tecnologias médicas de visualização do corpo humano e do cérebro no século XX, desde os raios X até as imagens mais sofisticadas de CT, IRM e PET. Pretende-se explorar as modificações na corporeidade resultantes da crescente visualização, assim como a recepção dessas tecnologias em tribunais e na cultura popular, especialmente na literatura, no cinema e nas revistas de divulgação.
In today's societies, successful new medical imaging technologies have focused unprecedented attention on the inside of the human body. These techniques have jumped the walls of the biomedical field per se, penetrating the fields of culture and law. The article traces a genealogy of twentieth-century medical techniques used to visualize the human body and brain, from X-rays to the more sophisticated CTs, MRIs, and PET scans. It explores the changes that these ever more numerous visualization techniques have occasioned in our corporality and examines how these technologies have been received in the courtroom and in popular culture, especially in literature, movies, and magazines.
Subject(s)
History, 20th Century , Humans , Diagnostic Imaging/history , Culture , Diagnostic Imaging/trends , Neurosciences/history , Visible Human Projects/historyABSTRACT
O estudo tem por objetivo discutir as bases biológicas sobre as quais se desenvolveu a neuropsicologia contemporânea, com o intuito de fornecer subsídios a educadores interessados no estudo das dificuldades e dos distúrbios de aprendizagem. Uma teoria da aprendizagem efetiva deve levar em conta os substratos anatômicos cerebrais e os mecanismos neurofisiológicos do comportamento, pois só assim o educador poderá compreender o não-aprender do aluno e, consequentemente, adotar estratégias adequadas para supera-lo.
The objective of the present review is to discuss biological bases of contemporary neuropsychology with the purpose to provide fundamental concepts to educators interested it the study of learning disabilities. An effective learning theory must consider brain and mental processes since in this only case the educator can understand why the student doesn't learn, and so can adopt adequated strategies to improve his/her cognitive rehabilitation.